Endocrine Abstracts

Over 70% of breast tumours express oestrogen receptor alpha (ERa). Stimulation with oestradiol results in receptor binding to oestrogen response elements (ERE) in target gene regulatory sequences in association with transcription cofactors, and altered gene expression, resulting in proliferation and tumour growth. Our study aimed to systematically identify genes contributing to ER signalling and oestrogen-dependent proliferation in breast cancer. A genome-wide screen for genes...